Objective To explore an optional condition to induce mouse embryonic stem ( ES) cells to differentiate into endothelial cells and to establish in vitro models of vasculogenesis and angiogenesis. 目的探讨体外定向诱导胚胎干细胞向内皮细胞分化的条件,模拟体内血管生成和血管新生过程,为研究新血管的形成提供一种新思路。
Fasudil promotes migration and vasculogenesis of endothelial cells differentiated from rat bone marrow mesenchymal stem cells in vitro 法舒地尔促进大鼠骨髓间充质干细胞分化生成的内皮细胞迁移及血管新生
Thin-layer collagen gel, microscope slide chamber and aorta-strip model were also tested and proved to be good tools for vasculogenesis or angiogenesis studies. 该工作表明,改进的薄层胶原培养、玻片培养小室模型和动脉条模型是较好的研究血管生成和血管新生的工具。
Endothlial progenitor cells ( EPCs) can differentiate into vascular endothelial cells and play an important role in vasculogenesis in adult. 内皮祖细胞是一类能分化成血管内皮细胞的前体细胞,在成人血管发生中起着重要作用。
In the present paper, we observed the postnatal vasculogenesis in the kidneys of neonatal rats through the method of the vascular corrosion casts and scanning electron microscopy. 应用血管铸型和扫描电镜方法,对新生大鼠肾脏血管系统的生后发育进行了观察。
Bone-marrow-derived endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization 骨髓源性血管内皮前体细胞与出生后生理性和病理性血管形成
In adult, EPCs in the peripheral circulation derive from bone marrow ( BM). They recruit and home at ischemic tissue to improve the function of ischemic organs through vasculogenesis and angiogenesis. Therefore EPCs has great potential for clinical application. 成年个体外周血中的EPCs来源于骨髓(bonemarrow,BM),可以募集、归巢到缺血部位,通过介导局部血管生成和血管新生改善缺血器官的功能,具有良好的临床应用前景。
Conclusion Rapamycin decreases the number, proliferative, migratory, adhesive and in vitro vasculogenesis capacity of EPCs. 结论雷帕霉素降低EPCs的数量、增殖能力、迁移能力、黏附能力和体外血管形成能力,并呈浓度和时间依赖性。
CONCLUSION: Transplantation of stem cell can induce vasculogenesis, which has become the new therapy of limb ischemia. 结论:干细胞移植能促进下肢血管新生,已成为治疗下肢缺血性疾病的新方法。
Vasculogenesis and angiogenesis are two different process. 血管新生(angiogenesis)和血管生成(vasculogenesis)是两个截然不同的过程。
Conclusions Ephrin-B2 may play an important role in the development and vasculogenesis of the glioma. B2在胶质瘤发生、发展和血管生成中可能有重要作用。
When cultured in three-dimensional matrix, the cells were elongated and migrated into the gel, with a phenotype similar to that in the process of angiogenesis and vasculogenesis in vivo. 而在三维胶原培养模式中,内皮细胞呈长梭状形态,并迁入胶原培养介质中,和体内血管新生及血管生成过程中的内皮细胞活化表型相似。
The angiopoietin ( Ang) family is a series of angiogenic factors, participating in the physiological and pathological vasculogenesis. 血管生成素(Ang)家族是一类促血管生成因子,参与生理性及病理性的血管生成。
Conclusions: BPH is related to vasculogenesis. 结论:BPH与血管形成有关。
Vascular endothelial progenitor cells ( EPCs) participate not only embryonic vasculogenesis but also postnatal vascular repair, generation and growth of tumour. 血管内皮祖细胞不仅参与胚胎期血管的生成,而且也参与出生后血管的修复、再生及肿瘤的生长等过程。
It is concluded that hematopoietic cells and endothelial cells in blood island of yolk sac, mesonephros and dorsal aorta co-expressed some factors and their receptors in relation to vasculogenesis and hematopoiesis. 结论:人胚胎卵黄囊血岛造血细胞和内皮细胞以及背主动脉和中肾共表达多种与血管发生和血液发生相关的因子。
The paper mainly introduced the mechanism of angiogenesis and vasculogenesis in uterus and placenta during early gestation and some influence factors. 文章主要介绍了妊娠早期子宫和胎盘中血管发生和血管新生的机制及其影响因素。
Cardiac vascular formation is a complex process and is the result of vasculogenic, angiogenic and arteriogenic mechanisms. 心脏的血管形成是血管发生(vasculogenesis)、血管生成(angiogenesis)及动脉生成(arteriogenesis)三种机制共同作用的结果。
Although the quantity of stem cell is limited, transplantation of stem cell with cell factor has better effect on vasculogenesis. 用来移植的干细胞数量有限,干细胞联合细胞因子移植具有更强大的促血管新生的作用。
Present results also suggested that zebrafish as a quality model for study on vasculogenesis and angiogenesis during embryonic development and screening for angiogenic enhancer or inhibitors. 斑马鱼是研究胚胎发育早期微血管发生和血管发生的极佳动物模型,可用于促血管发生或抑制血管发生药物筛选。
However, bone marrow derived endothelial progenitor cells have been isolated from peripheral circulation and shown to be incorporated into foci of physiological and pathological neovascularization, consistent with postnatal vasculogenesis in recent years. 然而,近年来发现循环中存在骨髓来源的血管内皮祖细胞,并与出生后血管发生密切相关,具有重要的生理、病理意义。
However, factors, the receptors and related signaling transduction molecules involved in vasculogenesis remains to be elucidated. 然而,目前的血管发育研究对参与血管发生的细胞因子、受体以及相关的信号转导分子的了解还十分局限,参与血管发生的重要调控因子仍有待实验研究来发现。
Vascular endothelial growth factor ( VEGF), a key regulator of angiogenesis and vasculogenesis, is involved in a variety of physiological and pathological processes. VEGF,作为血管新生和血管生成的一个主要的调节因子,参与多种生理和病理条件下的血管形成过程。
Furthermore, the biology and optical clarity of zebrafish embryos allows testing at all stages of embryonic development, such as organogenesis, vasculogenesis, and deleterious effects during anatomical development. 而且,斑马鱼胚胎的透明特征使得实验中可以直接观察胚胎发育的各个时期,包括器官形成,血管形成和毒性反应中形态学的变化。
Osteoblast and vescular endothelial cell, which are most related to bone regeneration and vasculogenesis, as well as the interaction of these two kinds of cells are the hotspot of correlated field. 与骨重塑及骨内血管发生密切相关的两种细胞&成骨细胞和血管内皮细胞,以及二者间的相互作用是相关领域研究的热点内容。
Neovascularization, or vasculogenesis, is the de novo formation of new blood vessels through the mobilization and recruitment of bone marrow-derived cells ( BMDCs). 血管新生,是通过动员和募集骨髓来源细胞形成新的血管。
EPCs can not only participate in vasculogenesis in embryonic period but also contribute to vascular repair and neovascularization. 它们不仅参与胚胎时期的血管发生,也存在于成年体内的骨髓和外周血中,参与血管的修复和新生。
Group E proteins play roles in vasculogenesis and negative regulation of development. E类蛋白在血管形成过程中发挥重要作用。
The VEGF can promote vasculogenesis. VEGF能够促进血管的形成。
The SDF-la/ CXCR4signaling also has a vital role in glioma invasion, as well as in glioma proliferation or vasculogenesis. SDF-1α/CXCR4信号通路还在胶质瘤侵袭、增生和血管生成中扮演重要角色。