Mutation Analysis on the Pathogenic Gene for Van Der Woude Syndrome 范德伍兹综合征致病基因的突变检测
Van der Woude syndrome ( VWS, OMIM 119300) is an autosomal dominant craniofacial disorder characterized by pits of the lower lip, hypodontia and cleft lip and/ or cleft palate. 范德伍兹综合征(VanderWoudesyndrome,VWS,OMIM119300)是一种常染色体显性遗传病。其特征是家族性下唇瘘复合唇裂或腭裂,1/4的患者伴有缺牙(Hypodontia)。
Congenital lower sinuses are rare and are found often in association with cleft lip and/ or palate, named Van der Woude syndrome. 先天性下唇窦道是较罕见畸形,常伴有唇和/或腭裂,又称作VanderWoude综合征。