Non-random XCI was not the main XCI pattern in RTT patients. The priority inactive X chromosome was mainly of paternal origin. RTT患儿非随机失活的X染色体主要起源于父亲。
After long-term culture, epigenetic status of these cells changed, XIST gene expression could be detected accompanied by the occurrence of XCI. 6. 长期培养后,伴随XCI的发生,XIST基因表达可检出。
The XCI pattern in these cells can be maintained stability after differentiation. 失活状态在细胞分化后可以稳定的维持。