histone

1. SET domain proteins contain conserved SET domains, which intensively involved in histone methylation.
   SET蛋白是一类包含保守的SET结构域、与组蛋白甲基化密切相关的蛋白质。
2. The changes of histone chemical modification play definite important role in the benezen's hematopoietic toxicity.
   组蛋白化学修饰可能在苯代谢物所致的造血毒性中发挥一定的作用。
3. Objective: To improve the synthetic procedure of the histone deacetylase ( HDAC) inhibitor SAHA.
   目的：改进组蛋白去乙酰化酶抑制剂SAHA的合成工艺。
4. The repressive mark was composed of three methyl groups attached to a lysine on the H4 histone.
   抑制性标记由3个甲基基团组成，结合到组蛋白H4的一个赖氨酸残基上。
5. Then specifc subtypes of nucleosomes are isolated with the aid of antibodies against particular histone variants.
   然后，核小体的特定亚型被抗特定组蛋白变异的抗体所分离。
6. The discovery of the histone lysine demethylases has strongly demonstrated that histone lysine methylation is a reversible epigenetic modification.
   组蛋白赖氨酸甲基化是组蛋白尾段发生的一种重要共价修饰，在基因的表观遗传转录调控中起着关键的作用。
7. Studies had shown that acetylation and deacetylation of histone are of certain value on T, B cell's development, differentiation, maturation, secretion and surface factor's expression etc.
   研究表明，组蛋白的乙酰化与去乙酰化状态，可作用于T、B细胞的发育、分化、成熟、分泌及表面因子的表达等多个方面。
8. The association and dissociation of DNA and histone in vitro was related to the ionic strength of their solution environment.
   本文研究小牛胸腺DNA和组蛋白在体外低、高离子强度盐溶液中的动态缔合与解离。
9. Molecular Mechanisms of Histone Acetylation Modification in Regulation of Hsp Gene Expression and Lifespan in Drosophila Melanogaster
   组蛋白乙酰化修饰调控果蝇热休克基因表达和寿命的分子机制研究
10. Study on the Ability of Transporting DNA of Histone H1 and TAT Fusion Protein
    组蛋白H1和TAT融合蛋白向细胞内转运DNA能力的研究
11. Molecular Cloning and Analysis of Histone H3 Genes from Triticum Aestivum
    普通小麦编码组蛋白H3基因的克隆与分析
12. Effect of Different Types and Treatments on the Level of Histone Acetylation in the Sheep Donor Cells and Cloned Embryos
    不同类型和处理对绵羊体细胞及克隆胚组蛋白乙酰化水平的影响
13. The changes of epigenetics such as DNA methylation and histone modification can regulate the expression of genes and play an important role in the development of tumors.
    表遗传学改变，如DNA甲基化和组蛋白修饰改变可以调节基因的表达，在肿瘤的发生和发展中可能起关键作用。
14. Epigenetic variation plays an important role in plant growth and development, including DNA methylation, histone modification, chromosome remodeling, and RNA interference and so on.
    表观遗传变异对于植物的生长发育起着重要作用，主要包括DNA甲基化、组蛋白修饰、染色体重塑和RNA干涉等。
15. Chromosome banding patterns are correlated with unique patterns of histone modifications.
    染色体带型和组蛋白修饰的特有模式相关。
16. The Effect of DNA Methylation and Histone Modification on the Development of Cloned Embryos
    DNA甲基化与组蛋白修饰对克隆胚发育的影响
17. A nucleoprotein whose protein component is a histone.
    核组蛋白蛋白成分是组蛋白的核蛋白。
18. The silenced state is correlated with repressive histone and DNA methylation marks in the D1 promoter region but is not associated with DNA sequence alterations.
    基因沉默的这种状态与D1基因启动子中的组蛋白甲基化和DNA甲基化修饰受抑制有关，而不涉及DNA序列的改变。
19. Differential histone modification marks of active versus repressed genes accompany these DNA methylation changes.
    活化的差异组蛋白修饰标记物对抑制基因的改变伴随着这些DNA甲基化改变。
20. As a epigenetic mark for the centromeric chromatin, CENP-A is a histone H3-like protein specific to centromeres.
    CENP-A作为着丝粒染色质的表观遗传学标记，是染色质核心组蛋白H3在着丝粒上的特异变体。
21. Effect of Trichostatin A ( TSA) on Histone Acetylation and Methylation in Bovine Fibroblast Cells
    曲古抑菌素A对体外培养牛成纤维细胞组蛋白乙酰化和甲基化的影响
22. Contrast to HMG histone H1 showed obvious inhibition effect on transcriptional activity of all of the rat liver nuclei.
    相反，组蛋白H1则可抑制各年龄组鼠肝细胞核的转录活性。
23. Several epigenetic drugs targeting DNA methylation and histone deacetylation enzymes have been tested in clinical trials.
    靶向DNA甲基化和组蛋白去乙酰化酶的几个表观药物已经在临床试验中被测试。
24. We demonstrated a direct role for histone modifications in alternative splicing.
    我们证明了组蛋白修饰在选择性剪接中一个直接的作用。
25. Effects of DNA Demethylation and Histone Deacetylase Inhibition to Estrogen Receptor of Prostate Cancer Cell-Lines
    去甲基化抑制剂和组蛋白去乙酰化转移酶抑制剂对前列腺癌细胞株雌激素受体的影响
26. The inhibition of the histone deacetylase enzymes induces hyperacetylation of the histone proteins.
    组蛋白脱乙酰酶的抑制引起了组蛋白的高乙酰化。
27. Many studies have explored the mosaic patterns of DNA methylation and histone modification in cancer cells on a gene-by-gene basis;
    很多研究已经在逐基因地基础上探寻了癌症细胞中DNA甲基化和组蛋白质修饰的镶嵌模式；
28. Histone proteins both protect DNA and regulate genes as they combine with DNA to form chromatin.
    组蛋白既保护DNA也在它们与DNA结合形成染色质时调节基因表达。
29. Histone marks affect splicing outcome by influencing the recruitment of splicing regulators via a chromatin-binding protein.
    组蛋白标记经由一个染色质结合蛋白质，通过影响剪接调控子的招募而影响剪接结果。

noun

1. a simple protein containing mainly basic amino acids